Cannabis, Indian Hemp or rather marijuana may provide the
novel treatment for prostate cancer by acting as analgesia on bone pain,
improving quality of life, while reducing narcotic consumption and
preventing opioid dependence. CHUKWUMA MUANYA writes.
THE
verdict is out: besides its use in the treatment of diseases and health
problems such as Human Immuno-deficiency Virus (HIV)/Acquired Immune
Deficiency Syndrome (AIDS), glaucoma, eye problems, cachexia (wasting
syndrome), pain, muscle spasticity, convulsion, insomnia, asthma,
hypertension, depression, among others; Cannabis sativa also called
Indian hemp or marijuana has been confirmed to be effective in is
managing prostate cancer patients.
Cannabis sativa, more commonly known as
marijuana, is a hemp plant that grows freely throughout the world. The
cannabis plant most commonly is known today as a potent psychoactive
substance, but for many years it was harvested primarily for its fibre.
Researchers in a study published recently in Indian Journal of Urology
concluded: “It is our conclusion that it would be of interest to conduct
clinical trials involving medicinal cannabis or other cannabinoid
agonists, comparing clinical markers such as Prostate Specific Antigen
(PSA) with controls, especially in men with bone metastatic prostate
cancer, whom would not only benefit from the possible anti-androgenic
effects of cannabinoids but also from analgesia of bone pain, improving
quality of life, while reducing narcotic consumption and preventing
opioid dependence.”
Cannabinoids are present in Cannabis sativa
and occur naturally in the nervous and immune systems of animals. They
are structurally related to tetrahydrocannabinol (THC) or that bind to
cannabinoid receptors.
PSA is screening test for prostate cancer.
An opioid is any psychoactive chemical that resembles morphine in its pharmacological effects.
The study titled “The role of cannabinoids in prostate cancer: Basic
science perspective and potential clinical applications” was published
by Juan A. Ramos and Fernando J. Bianco.
Also, Nigerian
researchers from Adekunle Ajasin University, Akungba –Akoko, Ondo State,
in study published in IOSR Journal of Pharmacy Vol. 2, Issue 3,
May-June, 2012, pp.460-463 concluded: “Cannabis sativa (marijuana) is a
wonderful and sacred plant that is grown all over the world. It is a
plant, which is plagued, ignorantly, with suspicions and controversies
that greatly prevented its usefulness to mankind.
“Apart
from being used for recreational purposes, Cannabis sativa is useful for
the treatment of some chronic diseases which defied medical cure such
as HIV/ AIDS, cancer, asthma etc. Marijuana is also a plant that has
some commercial and economical value.
“Consequent upon these
values, it is recommended that: Cannabis sativa should be legalised so
that it can provide employment for the producers, distributors and
traders of the commodity. More researches should be carried out on
Cannabis Sativa so that mankind could harness the Medical, commercial,
agricultural, social, recreational and economic utility inherent in then
crop.”
Dr. G.O. Ayenigbara of the Human Kinetics And Health
Education Unit, Science And Technical Education Department, Adekunle
Ajasin University, Akungba – Akoko, Ondo State, published the study
titled “Medical Utility of Cannabis Sativa”.
Despite the
medicinal uses, marijuana has been shrouded in controversy. There are
three hypothesized social\environmental consequences of Cannabis use
that have received attention, the role of marijuana in enhancing
interpersonal skills, the effect of Cannabis on aggression and violence,
and the role of marijuana use in what has been called the amotivational
syndrome. Many users of marijuana have s aid they use the drug because
it enhances their social skills and allows them to be more competent in
social situations.
Prostate cancer is an established public
health concern in modern society and has been for decades. It is the
most common cancer in men and the second most common cause of cancer
death in most countries.
Even with widespread screening with
prostate-specific antigen (PSA), still five per cent of cases present
with metastatic lesions at the time of diagnosis. Because of all this,
there is a fundamental necessity to search for and find new and novel
treatments to this common pathology.
Cannabis and cannabinoids
have often been an issue of much polemics in the realm of science, but
since the discovery of cannabinoid receptors in rat brain in the late
1980s, there has been a growing interest in the research of these
compounds and the knowledge continues to expand. There has been
experimental evidence that cannabinoids possess anti-androgenic
proprieties.
The researchers wrote: “Prostate cancer is a grave
public health problem worldwide. Despite the fact that most cases
currently present with localized disease, at the time of diagnosis,
about five per cent of men still present with metastatic disease.
“The most common site of spread is bone, and these lesions are
frequently symptomatic, causing pain, debility, and functional
impairment. Many of these men do not have curative treatment options,
and this remains a crucial clinical problem, both in terms of the number
of men affected and its impact on their quality of life. For these
reasons, it is fundamental to invest time and intellectual resources
into finding new and novel targets for the treatment of prostate cancer.
“It seems that the studies of Sarfaraz and colleagues lead to the
direction that cannabinoids should be considered as agents for the
management of prostate cancer, pending support from in vivo experiments.
This would not only make sense from an anti-androgenic point of view
but also for men with bone metastatic prostate cancer, perhaps from a
pain management or palliative point of view. Among the patients
suffering with chronic pain and receiving opioids, one in five abuse
prescription controlled substances, and it is not difficult to see that
opioid dependence and abuse is becoming a public health problem.
Different methods of managing pain should be addressed to avoid these
scenarios.
“The presence of pain in men with advanced prostate
cancer is an immediate indication for aggressive management with
analgesics, while adequate treatments that address directly the cause of
the pain are pursued.
“Cannabinoids possess attributes that
have impact in both cancer pain and prostate cancer pathophysiology.
These compounds harbor analgesic properties that aid bone cancer pain,
reduce opioid consumption, side effects, and dependence, as well as
exhibiting anti-androgenic effects on experimental prostate cancer
cells.
“Cannabis sativa and its main active component
delta-9-THC have long been used for numerous purposes throughout history
including medicinal, textile, and recreational. Since its legal banning
in the United States in 1937, it has become an issue of taboo and
controversy, frowned upon for its recreational uses and psychotropic
effects.
“Nonetheless, the endocannabinoid signaling system has
recently been the focus of medical research and considered a potential
therapeutic target since the late 1980s when Howlett and colleagues
identified and characterised the distinct cannabinoid receptor in rat
brain.
“The antagonising effect of cannabinoids in the male
reproductive system and physiology can be dated to 1974 where
experimental models in male rats showed depression of spermatogenesis
and decrease in circulating testosterone levels.
“In 2005,
Sarfaraz and colleagues showed increased expression of both CB1 and CB2
receptors in cultured prostate cancer cells when compared with normal
prostate cells, treatment of prostate cancer cells with cannabinoid
CB1/CB2 agonist WIN-55, 212-2 results in a dose and time dependent
decrease in cell viability, and increased apoptosis along with decrease
in androgen receptor protein expression, PSA expression, and secreted
PSA, suggesting that cannabinoids should be considered as agents for the
management of prostate cancer.”
According to the Adekunle
Ajasin University study, the plant is one of the most hated, maligned
and detested any where in the world and huge sums of money and efforts
are being expended to annihilate its production, distribution, marketing
and consumption.
Aiyenigbara wrote: “Cannabis sativa is
erroneously believed to cause deleterious health problems among other
controversies. However, studies have shown that this plant, apart from
being regarded as one of the five sacred crops, has a lot of medical,
recreational, commercial and social uses. Evidences have also shown that
marijuana is useful in the control and management of chronic diseases
such as HIV/AIDS, cancer, asthma, glaucoma, cachexia, hypertension,
depression, etc. Nevertheless, further research is required to make this
wonderful plant more useful to humanity.”
Marijuana is a
wonderful plant that is known and grown all over the world. This plant
is so popular and revered to the extent that it was worshipped in India.
The plant has a lot of uses commercially, agriculturally, medically and
socially. The leaves, the stems including the outer covering of the
back are very useful.
While the leaves are smoked
recreationally, the stem has been known to be used for producing the
strongest rope and pot ship builders used marijuana ropes in ship sails.
Evidences have also shown that the hemp fibers were employed in the
production of clothes and pots. According to Maisto, Galizio &
Connors, Hemp fibres were also used for house building in Southern
Africa.
Medically, Indian hemp has been used in the treatment of
diseases and health problems such as HIV/AIDS, glaucoma, eye problems,
cachexia, treatment of pain, muscle spasticity, convulsion, insomnia,
asthma, hypertension, depression etc. Moreover, cannabis was consumed
for recreational purposes. Besides, cannabis is being used as a shampoo
and for other cosmetic purposes. In addition, the cultivation of
cannabis is a lucrative business that yields substantial revenue to
producers and marketers locally and internationally.
The
therapeutic uses of marijuana today are much more circumscribed. For the
most part, synthetic products such as Levontradol, Nabilone, and
Marinol, that chemically resemble the Cannabinoids have been used in
current treatment efforts. These synthetics are used because they
provide the active elements of tetrahydrocannabinol (THC) in a more
stable manner, Synthetics also can provide better solubility.
Nevertheless, it was Cannabis THC that opened he way for the synthesis.
And rapid effect is experienced when marijuana is smoked than when the
synthetic THC is taken orally. Therefore, marijuana in its natural form
is more efficacious and faster in action than synthetic THC.
There has been a recent resurgence in efforts to legalise, marijuana for
medicinal purposes. Much of this effort has been spurred by an
increased use of marijuana by AIDS patients who claim that marijuana
reduces the nausea and vomiting caused by the disease and because it
stimulates appetite, thus helping them to regain weight lost during
their illness. The sympathy for this position led to the establishment
of “Cannabis clubs” on several major cities in the United States. These
organizations purchases marijuana in bulk and provide it, in some cases,
free to patient with AIDS, cancer and other diseases.
According
to the Adekunle Ajasin University study, specific health problems for
which cannabis is prescribed in synthetic forms are:
Glaucoma: Glaucoma is a generic term used to denote ocular diseases involving increases in intraocular pressure.
This pressure damages the optic nerves and represents the leading
causes of blindness in the United States. While drug and surgical
interventions are available, their effectiveness is variable. Cannabis
has been shown to decrease intraocular pressure, therefore, it is
preventive, although patients have experienced side effects regardless
of whether the Cannabis was administered orally, through injection or by
smoking.
Nausea and Vomiting:Cannabis and THC synthetics have
been used to counter the nausea and vomiting frequently associated with
chemotherapies for cancer. Positive outcomes have continued toe emerge
from the use of marijuana by cancer patients and particularly that
children undergoing cancer chemotherapy may benefit from administration
of orally administered high doses of Cannabinoids.
Even though
THC has some side effects, many patients undergoing chemotherapy find
the THC side effects an acceptable price to pay.
Cachexia: Cachexia is a disorder in which an individual physiologically “wastes away” often due to HIV infection or Cancer.
Based
partly on anecdotal reports that marijuana use is associated with
increased frequency and amount of eating, it could be proposed that
marijuana be used with patients with cachexia to stimulate appetite and
thus weight gain. Besides, appetite and weight may also produce strength
and a sense of well being. These anecdotal reports have some empirical
support. Plasse et al (1991) found a relationship between marijuana
ingestion and appetite. Accordingly, some individuals experiencing
disorders that include cachexia have been turning to marijuana to stem
the tide of weight loss and to gain weight.
Other Medical Uses:
Literature, according to Maisto, Galizio and Connors (1999), have shown
that Cannabis and THC synthetics have been used to a much extent in the
treatment of pains, muscle spasticity, convulsant activity, insominia,
hypertension, asthma and depression. However, the data in support of
these uses have been equivocal (Workshop on the Medical Utility of
Marijuana, 1997). More research is needed to identify the utility of
Cannabis in medical treatment of these and other disorders.
Agricultural and commercial uses of Cannabis sativa: The Cannabis plant
for many years was harvested primarily for its fiber. These strong hemp
fibers were employed in the production of rope, clothes and ship sails
(Maisto, Galizio and Connors 1999). Archeologists at a Taiwanee site
also discovered pots made of fibers presumed to be from the Cannabis
plant. In the North American Colonies, the Cannabis plant was raised for
fiber by the Jamestown settlers in Varginia in 1611. Not long after,
this hemp plant was firmly entrenched as a basic stable crop and was
cultivated by George Washington, among many others. Cannabis was
harvested in New England starting 1629, it remained a Core U.S Crop
until after the civil war. The center of this hemp production was
Kentucky, where it was a major crop product for decades, all for its
fiber content.
Recreational Uses: Cannabis was consumed for
recreational purposes, though, only to a limited degree, and
descriptions of its psychoactive effect were not common. However, the
1920s marked a wider use of Cannabis. Increased use of marijuana was
attributed to alcohol prohibition. According to Brecher (1972), not
until the eighteenth amendment and the Volstead Act of 1920 raised the
price of alcohol beverages and made them less convenient to secure and
inferior in quality did substantial commercial trade in marijuana for
recreation use spring up, and the popularity soared, and that popularity
has remained strong ever since.
Author of this article:
CHUKWUMA MUANYA
Source: http://www.ngrguardiannews.com/natural-health/131865-cannabis-may-provide-novel-cure-for-prostate-cancers